What are TET and ZIFT ?
TET involves taking eggs from the woman, fertilizing them in the laboratory with her partner's sperm and transferring the resulting embryos back to her fallopian tubes 2 days after fertilization (at the 2-cell to 4-cell stage).
ZIFT involves taking eggs from the woman, fertilizing them in the laboratory with her partner's sperm and transferring the resulting embryos back to her fallopian tubes the day after fertilization (at the one-cell or zygote stage).
Both of these procedures require a surgical procedure called laparoscopy to transfer the embryos.
Who should be treated with TET and ZIFT ?
TET and ZIFT can be used as an effective treatment for infertility of all causes except for women with infertility caused by tubal blockage or significant tubal damage, or an anatomic problem with the uterus, such as severe intrauterine adhesions.
It is generally used in couples who have failed to conceive after at least one year of trying who also have one or more of the following: Failed 3-6 cycles of ovarian stimulation with intrauterine insemination
TET and ZIFT vs IVF
Some studies have shown higher implantation rates with ZIFT/TET as compared to in vitro fertilization (IVF) with uterine embryo transfer or GIFT.
Patient selection is usually a potential confounding issue. Few randomized trials have been done. Those that have either show no difference or a benefit to tubal transfers.
How are TET and ZIFT performed ?
Consents are signed by all parties. The woman is stimulated with medications to develop multiple egg development. When the woman's follicles are mature, an aspiration procedure is performed to remove the eggs from her ovaries. The eggs are then fertilized in the laboratory with her partner's sperm.
The embryos are cultured in the laboratory for 1 day for ZIFT and 2 days with TET. At that time, a tubal transfer procedure (surgery with laparoscopy) is done which places the embryos in the woman's fallopian tubes.
Cost of TET and ZIFT in India
TET and ZIFT cost more than IVF because of the surgical procedure involved in the transfer. They also cost more than GIFT because of the additional expenses involved with embryo culture and because the transfer procedure is done on another day - as compared to GIFT where the aspiration and transfer procedures are done on the same day.
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